SAFE. EFFECTIVE. BACKED BY SCIENCE.
CogGevity’s proprietary formula includes 6 key ingredients:
Longvida™ Optimized Curcumin††
A natural antioxidant found in the root of the turmeric plant, curcumin, supports healthy brain cells and improves cognitive function. CogGevity has a highly-bioavailable and patented form of curcumin that is absorbed into the bloodstream for maximum effect. The curcumin formulation in CogGevity is backed by considerable research and clinical trial data.
Scienific/Clinical Trial References: One limitation to reaching the beneficial potential of Curcumin is the question of bioavailability (i.e., the ability to be absorbed into the body and metabolized), as orally administered is not easily absorbed. The summaries of the studies below demonstrate the bioavailability of Curcumin on biomarkers in healthy human adults and highlight the emerging research on its potent ability to support brain health. CogGevity™ uses Longvida(R) Optimized Curcumin, which has been shown to be highly bioavailable.
DiSilvestro RA et al., Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people.Nutrition Journal 2012; 11:79. A low dose (80mg/day) of a curcumin-lipid preparation can produce a variety of various health promoting effects within a 4 week time frame as assessed by blood and saliva samples including lowering of salivary amylase activity, raising of salivary radical scavenging capacities, raising of plasma catalase activities, increased plasma nitric oxide levels and lowering of plasma beta amyloid protein concentrations in n=38 healthy middle aged people (40-60 yrs old).
Cox KH et al., Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. J of Psychopharmacology 2015;29(5):642-51. This randomized, double-blind, placebo-controlled trial measured the effects of solid lipid curcumin formulation (400 mg Longvida™ Optimized Curcumin which is the equivalent of 80 mg curcumin) on cognitive function, mood and blood biomarkers in 60 healthy adults aged 60-85. Improved performance on sustained attention (digit vigilance task) and working memory (serial three subtraction task) was enhanced upon acute treatment (1 and 3 hr after single dose) and working memory and mood (i.e. general fatigue, state calmness, fatigue induced by stress) were significantly improved following chronic treatment (4 weeks). This had no effect on hematological safety measures.
Ma QL et al., Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic and behavioral deficits in aged human tau transgenic mice, JBC 2013; 288(6): 4056-4065. Aged human Tau transgenic mice were fed diets with curcumin (Longvida-550 ppm) added to the chow. The results demonstrate that curcumin fed human Tau transgenic mice but not control mice had a reduction in soluble Tau dimers through the upregulation of heat shock proteins, which help to stabilize microtubules and support tau degradation, to confer neuroprotection. Furthermore, curcumin fed human Tau transgenic mice had improved behavioral performance and corrections in synaptic and heat shock protein deficits, suggesting bioavailable curcumin may provide critical brain support in aging adults.
For even more research and evidence into the benefits of Curcumin on brain health, please click here.
An essential Omega-3 fatty acid, DHA (docosahexaenoic acid) is a major structural component of the brain. DHA promotes optimal neuronal function and supports synaptic membrane structure and function, healthy neurotransmitter function, and supports the stability and fluidity of cellular membranes. It also promotes GABA, a chemical messenger in the brain; GABA is believed to help control fear and anxiety responses by reducing the activity of neurons to which it binds.
Scienific/Clinical Trial References: Summaries from the literature below demonstrate the efficacy of DHA supplementation to support overall brain structure and function.
Boespflug EL et al., Fish oil supplementation increases event-related posterior cingulate activation in older adults with subjective memory impairment. J Nutr Health Aging. 2016;20(2):161-9. This was a randomized, double-blind, placebo-controlled study in healthy older adults (62-80 yr) with subjective memory impairment who did not meet the criteria for mild cognitive imairment or dementia. Fish oil (EPA+DHA: 2.4 g/day) or placebo was administered to 21 subjects for 24 weeks and corticol BOLD response patterns were assessed by fMRI at baseline and week 24. The cohort receiving fish oil demonstrated increases in red blood cell omega 3 content, improved working memory performance and BOLD signals were enhanced in the posterior cingluate cortex in response to a working memory challenge. This study suggests dietary fish oil supplementation can support cognitive function in healthy older adults with subjective memory impairment.
Tan ZS, Harris WS, Beiser AS, et al. Red blood cell omega-3 fatty acid levels and markers of accelerated brain aging. Neurology. 2012;78(9):658-664. This study investigated the red blood cell count of omega-3 fatty acid levels (EPA and DHA) in dementia free Framingham Study participants (n=1,575; 854 women, age 67 ± 9 yr) to performance on cognitive tests and brain volumes as measured by MRI. Lower red blood cell DHA levels were associated with lower brain volumes, greater white matter hyperintensity volume and a vascular pattern of cognitive impairment even in people who are free of clinical dementia.
Docosahexaenoic acid and adult memory: a systematic review and meta-analysis. PLoS One. 2015;10(3):e0120391. DHA is a polyunsaturated fatty acid that is an integral part of the neural membrane phospholipid and research demonstrates a positive association between DHA dietary intake and cognitive function. This systematic literature review finds that 1g/day of DHA/EPA improved episodic memory. Furthermore, observational studies support and association between intake of DHA/EPA and memory function in older adults.
For even more research and evidence into the benefits of DHA on brain health, please click here.
Another important Omega-3 fatty acid, EPA (eicosapentaenoic acid) essential for brain health, that supports cognitive function.*
Scienific/Clinical Trial References: The literature summaries below reinforce the efficacy of EPA supplementation to support overall brain structure and function.
Pottala, JV et al., Higher RBC EPA+DHA corresponds with larger brain and total hippocampal volumes WHIMS-MRI study. Neurology. 2014; 82(5):435-442. Red blood cell EPA, DHA and MRI brain volumes were assessed in 1,111 postmeonpausal women from the Women ’s Health Initiative Memory Study. A higher omega-3 index was correlated with larger total normal brain volume and hippocampal volume (area of working memory) in women measured 8 years later.
Zamroziewicz MK, Paul EJ, Zwilling CE, Barbey AK. Determinants of fluid intelligence in healthy aging: Omega-3 polyunsaturated fatty acid status and frontoparietal cortex structure. Nutr Neurosci. 2017;1-10. Specific omega-3 polyunsaturated fatty acids have an impact on maintaining the structural integrity of a grey matter area vulnerable to age related decline in the brains of cognitively intact older adults.
Bauer I et al., Omega-3 supplementation improves cognition and modifies brain activation in young adults. Hum Psychopharmacol. 2014;29(2)133-44. This study investigated whether a 30 day supplementation period of omega 3 fatty acids (EPA rich versus DHA rich) had an impact on cognitive performance and brain activation as assessed by the Stroop and Spatial Working Memory Test and MRI, respectively. In a double blind, crossover design, with a 30 day washout period between the two supplements, investigators found that with EPA supplementation the subjects had a better cognitive performance than prior to supplementation. EPA supplementation resulted in a decrease in function in the left anterior cingulate cortex and an increase in activation in the right precentral gyrus during the Stroop task. Conversely, DHA supplementation was less effective than EPA on enhancing cognitive performance in the same group of subjects but it did increase functional activation of the precentral gyrus during the working memory tasks.
For even more research and evidence into the benefits of EPA on brain health, please click here.
An important flavonoid (plant phytochemical) found in certain fruits and vegetables, Fisetin† has been shown in animal studies to support memory and mental function.* Fisetin’s† antioxidant properties are believed to promote memory storage by forming strong connections between neurons in the brain, and Fisetin† may provide support against free radicals. Fisetin† has potent beneficial properties, and healthy circulation (i.e. cerebral blood flow) and mitochondrial function.*
Scienific/Clinical Trial References: The selected literature summaries below examine the neurobeneficial role of Fisetin on brain function and its potential to support the aging brain.
Maher P., How fisetin reduces the impact of age and disease on CNS function. Front Biosci. 2015; 1(7):58-82. Fisetin has multiple biological functions in the body including antioxidant protection, anti-inflammatory activity, increasing intracellular glutathione levels and it has been shown to impact neurotropic signaling pathways. This is a review of the novel neurobeneficial and cognitive-enhancing molecule fisetin.
For even more research and evidence into the benefits of Fisetin on brain health, please click here.
Decaffeinated Green Tea Extract
With naturally occurring polyphenols (compounds in plants that have antioxidant properties), green tea can help reduce the formation of free radicals in the body and have neurosupportive effects. Epigallocatechin gallate (EGCG), a polyphenol found in green tea, may also promote neuron creation and support cognitive function.*
Scienific/Clinical Trial References: The summary abstracts below give more depth on the research in support of Green Tea’s role in brain health, specifically with regards to cognition, mood and neuronal benefits.
Fernando W, Somaratne G, Goozee KG, Williams S, Singh H, Martins RN. Diabetes and Alzheimer's Disease: Can Tea Phytochemicals Play a Role in Prevention? J Alzheimers Dis. 2017; May 30. Doi:10.3233/JAD-161200. Tea has been shown to have potent health promoting benefits including antioxidant properties which can serve to support general brain health.s
Dietz C and Dekker M., Effect of green tea phytochemicals on mood and cognition. Curr Pharm Des. 2017.;Vol 23. Doi:10.2174/1381612823666170105151800. This article is a review of 49 human intervention studies investigating the effects on phytochemicals found in green tea including L-theanine, EGCG and caffeine on various aspects of mood (relaxation and alertness) and cognition (sustained attention and memory).
André Schmidt, Felix Hammann, Bettina Wõlnerhanssen, Anne Christin Meyer-Gerspach, Jürgen Drewe, Christoph Beglinger, Stefan Borgwardt. Green tea extract enhances parieto-frontal connectivity during working memory processing. Psychopharmacology, 2014; DOI: 10.1007/s00213-014-3526-1. In this study, the researcher teams of Prof. Christoph Beglinger from the University Hospital of Basel and Prof. Stefan Borgwardt from the Psychiatric University Clinics found that green tea extract increases the brain's effective connectivity, meaning the causal influence that one brain area exerts over another. This effect on connectivity also led to improvement in actual cognitive performance: Subjects tested significantly better for working memory tasks after the admission of green tea extract.In this study, the researcher teams of Prof. Christoph Beglinger from the University Hospital of Basel and Prof. Stefan Borgwardt from the Psychiatric University Clinics found that green tea extract increases the brain's effective connectivity, meaning the causal influence that one brain area exerts over another. This effect on connectivity also led to improvement in actual cognitive performance: Subjects tested significantly better for working memory tasks after the admission of green tea extract.
For even more research and evidence into the benefits of Green Tea on brain health, please click here.
Vitamin D supports overall brain structure and function and it works with Omega-3 fatty acids to support cognitive function and has powerful immune support, essential for brain health. CogGevity helps you meet your daily needs for this essential vitamin.*
Scienific/Clinical Trial References: The literature extracts below highlight the role of Vitamin D in supporting the aging brain and its role in optimal brain health.
Latimer CS et al., Vitamin D prevents cognitive decline and enhances hippocampal synaptic functioning in aging rats. PNAS. 2014;111(41):E4359-E4366. This study investigated whether increasing dietary vitamin D to optimal levels for a 6 month time frame could enhance cognitive function in aging rats. The research demonstrates that rats on high vitamin D significantly outperformed low and medium groups on challenging tasks involving memory. Synaptic transmission was also enhanced in the high vitamin D group. The findings suggest that vitamin D mediated changes in hippocampal gene expression may improve the likelihood of successful brain aging.
Groves et al., Vitamin D as a neurosteroid affecting the developing and adult brain. Annualreview of nutrition. 2014; 34:117-141. This is a review on the important roles of vitamin D in terms of its neurotropic and neuroprotective functions as well as its role in brain function as it applies to health.
For even more research and evidence into the benefits of Vitamin D on brain health, please click here.
Watch a short video about the 6 key ingredients in CogGevity and see how each ingredient has a specific role, function, and benefit in the brain.
NOURISH YOUR BRAIN WITH COGGEVITY™
ADVANCED BRAIN NUTRITION
The 6 key ingredients/nutrients in CogGevity have
individual health benefits while also working well together to help support brain health as you age.* Each ingredient has a specific role, function, and benefit in the brain.
With the questionable ingredients found in so many supplements today, it’s not surprising that consumers are growing increasingly concerned about product safety.
CogGevity is committed to safety and transparency. Each of the ingredients in our soft gel capsules has been clinically shown to safely and effectively provide different important benefits for brain health.*
COGGEVITY™ ADVANCED BRAIN NUTRITION BENEFITS
- Safe and effective*
- Unique blend of ingredients
- No side effects*
- Patented technology
- Money-back guarantee**
- Only $1 per day
**100% Satisfaction Money-Back Guarantee: If you are not completely satisfied with your purchase of CogGevity™ Advanced Brain Nutrition, simply mail the CogGevity bottle and the unused portion together with the purchase receipt within 30 days of original purchase date to CogGevity, C/O: World Pack Distribution, 8500 Rex Road, Pico Rivera, CA 90660. A refund will be issued to the credit card on file that is associated with your account. For detailed information, please see Terms & Conditions. Please note that a request for a refund will result in the cancellation of your participation in the subscription service (if applicable) for that product and all future automatic shipments of that product will cease.